Leflunomide CAS: 75706-12-6 Mai Bayar da Maƙera

Leflunomide ba shi da aiki, amma teriflunomide yana hana pyrimidine de novo kira a ƙananan maganin warkewa ta hanyar hana dihydroorotate dehydrogenase (ma'auni mai ƙayyade enzyme don kira na UMP), rage DNA da RNA kira, da kuma kama tsarin yaduwar kwayar halitta da kuma samar da kwayoyin rigakafi.Rage dihydroorotate zuwa orotate yana faruwa a lokaci guda tare da raguwar cofactor, ubiquinone (coenzyme Q).Hanawar dihydroorotate dehydrogenase ta teriflunomide yana nuna rashin gasa da rashin gasa.Gudanar da leflunomide a cikin marasa lafiya tare da cututtukan cututtuka na rheumatoid yana haifar da ci gaba da cire ƙwayoyin B da kuma tsarin tsarin rigakafi.