Leflunomide CAS:75706-12-6 Mai Kaya na Masana'anta

Leflunomide ba ya aiki, amma teriflunomide yana hana haɗa pyrimidine de novo a ƙananan allurai na magani ta hanyar hana dihydrorotate dehydrogenase (enzyme mai ƙayyade ƙimar don haɗa UMP), rage haɗa DNA da RNA, da kuma dakatar da zagayowar yaduwar ƙwayoyin halitta da samar da ƙwayoyin rigakafi. Ragewar dihydrorotate zuwa orotate yana faruwa a lokaci guda tare da rage cofactor ɗinsa, ubiquinone (coenzyme Q). Hana dihydrorootate dehydrogenase ta hanyar teriflunomide yana nuna rashin gasa da rashin gasa. Yin amfani da leflunomide ga marasa lafiya da ke fama da cututtukan rheumatoid yana haifar da ci gaba da cire ƙwayoyin B da rage tsarin garkuwar jiki.