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guanosine 5′-(disodium dihydrogen triphosphate) CAS:56001-37-7
Guanosine-5′-triphosphate disodium wani sinadari ne da ake amfani da shi a cikin hanyoyin sinadarai daban-daban, kamar a cikin haɗa RNA da DNA, da kuma a cikin hanyoyin watsa sigina. Triphosphate ne na nucleoside, wanda ke nufin ya ƙunshi guanosine na nucleoside wanda aka haɗa zuwa ƙungiyoyin phosphate guda uku. Siffar gishirin disodium kawai tana nuna cewa gishiri ne wanda ke ɗauke da ions na sodium guda biyu.
Wannan sinadari yana da mahimmanci wajen canja wurin makamashin tantanin halitta kuma yana da hannu a cikin nau'ikan halayen enzymatic daban-daban. Hakanan tushen kuzari ne don haɗa furotin da sauran hanyoyin tantanin halitta.
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2′-Deoxyuridine CAS:951-78-0 Farashin Mai Masana'anta
2′-Deoxyuridine wani nau'in nucleoside ne wanda ya ƙunshi nucleobase uracil wanda ke da alaƙa da sukari na deoxyribose. Yana da muhimmin tubalin gina DNA kuma yana da hannu a cikin kwafi da kuma kwafi na kayan kwayoyin halitta. Ana amfani da 2′-Deoxyuridine a cikin binciken kimiyya a matsayin abin da ya dace don haɗa DNA da kuma a cikin dabarun ilmin kwayoyin halitta daban-daban. Yana taka muhimmiyar rawa wajen fahimtar hanyoyin kwayoyin halitta, da kuma haɓaka yuwuwar amfani da magunguna a fannoni kamar maganin rigakafi da maganin ciwon daji.
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Adenosine5′-(trihydrogen diphosphate), gishirin monopotassium, dihydrate (9CI) CAS:72696-48-1
gishirin monopotassium na adenosine 5′-(trihydrogen diphosphate) dihydrate, wani sinadari ne na sinadarai wanda ya ƙunshi adenosine tare da rukunin trihydrogen diphosphate da gishirin monopotassium a cikin nau'in dihydrate. Wannan sinadari ana kiransa adenosine diphosphate (ADP), wanda ke taka muhimmiyar rawa a cikin hanyoyin halittu daban-daban, musamman a cikin canja wurin makamashi a cikin ƙwayoyin halitta.
ADP muhimmin sashi ne a cikin kuɗin kuzarin tantanin halitta, domin yana da hannu wajen canja wurin makamashi yayin numfashin tantanin halitta da photosynthesis. Hakanan yana da mahimmanci ga adenosine triphosphate (ATP), wanda shine babban mai ɗaukar makamashi a cikin tantanin halitta.
Bugu da ƙari, ADP yana da hannu a cikin hanyoyin canja wurin sigina kuma wani abu ne mai mahimmanci a cikin halayen enzymatic. Dangane da ilimin halittu da ilmin kwayoyin halitta, ana amfani da ADP sosai a cikin nazarin da suka shafi metabolism na ƙwayoyin halitta, motsin enzyme, da hanyoyin canja wurin makamashi.
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Hypoxanthine CAS:68-94-0 Farashin Mai Masana'anta
Hypoxanthine wani sinadari ne da ke faruwa a zahiri wanda ke tsaka-tsaki wajen lalata sinadarin purines. Yana da muhimmin sinadari a cikin sinadarin nucleic acid kuma yana da hannu a cikin wasu hanyoyin halitta, ciki har da hadawa da metabolism na DNA da RNA. Bugu da ƙari, an gano cewa hypoxanthine yana taka rawa a wasu yanayi na lafiya, kamar gout da cutar Lesch-Nyhan.
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2′-O-Methyluridine CAS:2140-76-3 Farashin Mai Masana'anta
2′-O-Methyluridine wani nau'in nucleoside ne da aka gyara wanda ya ƙunshi ƙungiyar methyl a matsayin 2′ na zoben ribose. Yana da muhimmin tubalin gini a cikin haɗakar ƙwayoyin RNA da aka gyara kuma an yi nazari a kansa saboda yuwuwar halayen halittu da na magunguna. Wasu daga cikin aikace-aikacen da aka ruwaito sun haɗa da amfani da shi a cikin binciken RNA, a matsayin wani ɓangare na samar da RNA da aka gyara don aikace-aikacen warkewa da aikin kwayoyin halitta, da kuma a matsayin kayan aiki a cikin nazarin tsarin RNA da aikin.
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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS:951-77-9
2′-Deoxycytidine wani nau'in nucleoside ne wanda ya ƙunshi cytosine na nucleobase wanda ke da alaƙa da sukari deoxyribose. Yana da muhimmin sashi na DNA kuma yana taka muhimmiyar rawa wajen adana bayanai na kwayoyin halitta da kuma watsa su a cikin halittu masu rai.
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Cytidine-5′-monophosphate (CMP), babu acid CAS:63-37-6
Cytidine 5'-monophosphate (CMP) wani nau'in nucleotide ne wanda ke aiki a matsayin tubalin gini don haɗa RNA da gyare-gyare. Yana da muhimmin sashi a cikin gina ƙwayoyin RNA kuma yana da hannu a cikin ayyuka kamar capping mRNA da metabolism na nucleotide. Haka kuma ana amfani da CMP a cikin binciken halittu na biochemical da molecular don aikace-aikace kamar rubutun in vitro da labeling nucleic acid. Matsayinsa a cikin metabolism na RNA da amfani da shi a cikin dabarun gwaji daban-daban ya sa ya zama kayan aiki mai mahimmanci wajen fahimtar tsari da aikin ƙwayoyin RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
3-isobutyl-1-methylxanthine, wanda kuma aka sani da IBMX, wani sinadari ne na methylxanthine wanda aka saba amfani da shi a binciken kimiyya a matsayin wani abu da ba shi da takamaiman tasiri ga cyclic nucleotide phosphodiesterases. An san shi yana ƙara matakan cyclic AMP (cAMP) da cyclic GMP (cGMP) a cikin ƙwayoyin halitta ta hanyar hana rushewar su, wanda hakan zai iya daidaita hanyoyin siginar ƙwayoyin halitta daban-daban.
Baya ga aikace-aikacen bincike da take yi, an yi amfani da IBMX a wasu wuraren kiwon lafiya don tasirin bronchodilator da vasodilator. Duk da haka, amfani da shi a cikin maganin ɗan adam yana da iyaka.
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4-Nitrophenyl phosphate disodium gishiri hexahydrate CAS:4264-83-9
4-Nitrophenyl phosphate disodium gishiri hexahydrate wani sinadari ne da ake amfani da shi a binciken sinadarai da magunguna. Siffa ce ta gishiri ta 4-nitrophenyl phosphate, wadda ke ɗauke da sodium ions guda biyu da ƙwayoyin ruwa guda shida. Ana amfani da wannan sinadari a matsayin wani sinadari don gwajin phosphatase da kuma nazarin motsin enzymes.
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5′-Deoxy-5-fluorocytidine CAS:66335-38-4
5′-Deoxy-5-fluorocytidine wani nau'in nucleoside ne da ake amfani da shi wajen gano yiwuwar tasirinsa na kashe ƙwayoyin cuta, musamman a kan ƙwayoyin cuta na RNA kamar cutar hepatitis C (HCV) da flaviviruses. Yana aiki ta hanyar hana kwafi na ƙwayoyin cuta, a ƙarshe yana hana ikon ƙwayar cuta ta ninka da yaɗuwa a cikin jiki.
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Cytidine-5′-triphosphate (CTP), gishirin disodium CAS:652154-13-7
Gishirin disodium, wanda aka fi sani da Cytidine-5′-triphosphate (CTP), wani sinadari ne na nucleoside triphosphate wanda ke aiki a matsayin tubalin gina RNA. Yana taka muhimmiyar rawa a cikin metabolism na tantanin halitta kuma yana da mahimmanci don canja wurin bayanan kwayoyin halitta daga DNA zuwa RNA yayin kwafi. Ana amfani da CTP sosai a cikin binciken ilmin kwayoyin halitta, musamman a cikin nazarin da ya shafi hada RNA, tsangwama na RNA, da sauran hanyoyin da suka shafi RNA. Bugu da ƙari, ana amfani da shi a cikin halayen enzymatic, nazarin metabolism na nucleotide, da kuma azaman madadin gwaje-gwajen biochemical daban-daban. A cikin masana'antar magunguna, CTP na iya samun damar amfani da shi wajen haɓaka magungunan rigakafi da maganin ciwon daji.
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ITP, inosine 5′-triphosphate gishirin trisodium CAS:35908-31-7
Gishirin trisodium na Inosine-5′-triphosphate, wanda aka fi rage shi a matsayin ITP-Na3, nau'in triphosphate ne na inosine, wani nucleoside wanda ke taka muhimmiyar rawa a cikin hanyoyin halittu daban-daban. Wannan sinadari sinadari ne na gishiri, wanda ke sa shi narkewa cikin ruwa kuma ya dace da amfani a cikin gwaje-gwajen sinadarai da enzymatic, da kuma a cikin binciken ilmin kwayoyin halitta. Ana amfani da gishirin trisodium na Inosine-5′-triphosphate don nazarin halayen enzymatic, canjin nucleotide, da kuma matsayin substrate ga wasu enzymes. Aikace-aikacensa kuma ya shafi nazarin analog na nucleotide da kuma a matsayin wani ɓangare na shirya gaurayen nucleotide da ake amfani da su a cikin dabarun ilmin kwayoyin halitta.
