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Adenosine CAS:58-61-7
Adenosine wani sinadarin nucleoside ne wanda ya ƙunshi adenine da ribose, wanda ke taka muhimmiyar rawa a cikin metabolism na ƙwayoyin halitta. Yana aiki a matsayin babban tubalin gina adenosine triphosphate (ATP), babban kuɗin makamashi a cikin tsarin halittu. Bayan ayyukansa masu alaƙa da makamashi, adenosine yana da hannu a cikin ayyuka daban-daban na ilimin halittar jiki, gami da watsawar jijiyoyi, vasodilation, da kuma daidaita zagayowar barci da farkawa. Yana aiki akan takamaiman masu karɓa, yana tasiri ga bugun zuciya da kwararar jini. A asibiti, ana amfani da adenosine a magani, musamman wajen magance wasu arrhythmias na zuciya. Ayyukansa masu fannoni da yawa suna nuna mahimmancin adenosine a cikin lafiya da cututtuka.
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Uridine 5-monophosphate, gishirin disodium CAS:3387-36-8
Uridine 5-monophosphate, gishirin disodium (UMP) wani nau'in nucleotide ne wanda ke taka muhimmiyar rawa a cikin metabolism na ƙwayoyin halitta da kuma haɗa RNA. Ya ƙunshi uracil na tushen pyrimidine, sukari na ribose, da rukunin phosphate, UMP yana da mahimmanci ga hanyoyin halittu daban-daban, gami da samar da nucleic acid da kuma daidaita hanyoyin rayuwa. Siffar gishirin disodium yana ƙara narkewa da kwanciyar hankali a cikin ruwan da ke cikin ruwan, wanda hakan ya sa ya dace da binciken dakin gwaje-gwaje da aikace-aikacen magani. UMP ta jawo hankali ga yuwuwar kariya daga jijiyoyi da haɓaka fahimta, da kuma rawar da take takawa wajen haɓaka lafiyar ƙwayoyin halitta gaba ɗaya.
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Cytidine 5′-(disodium phosphate) CAS:6757-06-8
Cytidine 5′-(disodium phosphate) wani abu ne da aka samo daga nucleotide wanda ya ƙunshi pyrimidine base cytosine, ribose sugar, da kuma ƙungiyar phosphate. Wannan mahaɗin yana taka muhimmiyar rawa a cikin hanyoyin sinadarai daban-daban, ciki har da haɗa RNA, hanyoyin sarrafawa, da siginar ƙwayoyin halitta. Tsarin gishirin disodium yana ƙara narkewa da kwanciyar hankali a cikin yanayin ilimin halittar jiki, wanda hakan ya sa ya dace da binciken dakin gwaje-gwaje da kuma yiwuwar amfani da shi wajen magance cututtuka. Cytidine 5′-(disodium phosphate) ya sami sha'awa saboda rawar da yake takawa a cikin metabolism na nucleic acid da kuma fa'idodin da zai iya bayarwa wajen haɓaka aikin fahimta da tallafawa lafiyar ƙwayoyin halitta.
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5-Azacytidine CAS:320-67-2
5-Azacytidine wani nau'in nucleoside ne na roba wanda ke ɗauke da sinadarin nitrogen a cikin matsayi na 5 na zoben pyrimidine, yana maye gurbin sinadarin carbon. Wannan gyaran yana ba da takamaiman kaddarorin magunguna, yana mai da shi muhimmin sinadari a fannin ilmin kwayoyin halitta da kuma maganin ciwon daji. A matsayin mai hana DNA methyltransferase mai ƙarfi, 5-azacytidine na iya sake kunna kwayoyin halittar da aka rufe ta hanyar canza tsarin methylation na DNA, ta haka yana tasiri ga bayyanar kwayoyin halitta. An ƙirƙira shi da farko don magance cututtukan jini, 5-azacytidine ya sami kulawa ga yuwuwar amfani da shi a cikin maganin epigenetic, maganin sake farfaɗowa, da bincike da ke niyya ga cututtuka daban-daban waɗanda ke da alaƙa da tsarin kwayoyin halitta mara kyau.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
2′-Fluoro-2′-deoxyuridine (FdU) wani nau'in nucleoside ne na deoxyuridine, inda aka maye gurbin sinadarin hydrogen a matsayin 2′ na sukari ribose da kwayar fluorine. Wannan gyaran yana ƙara kwanciyar hankali da aikin kwayoyin halitta na mahaɗin, wanda hakan ya sa ya zama mai amfani a binciken sinadarai da aikace-aikacen magani. An san FdU musamman saboda rawar da take takawa a matsayin maganin rigakafi da maganin ciwon daji, domin yana iya tsoma baki ga haɗakar DNA da kuma hana kwafi na wasu ƙwayoyin cuta da ƙwayoyin cutar kansa. Abubuwan da ke tattare da shi na musamman sun sa ya zama kayan aiki mai mahimmanci wajen haɓaka hanyoyin magance cututtuka da nazarin ilmin halitta.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one wani hadadden nucleoside ne wanda ke dauke da tushen pyrimidine da aka makala da sukarin ribose da aka gyara. Kasancewar atom na fluorine da rukunin hydroxyl a cikin tsarinsa yana kara inganta halayen sinadarai, wanda hakan ya sanya shi zabi mai ban sha'awa ga binciken kwayoyin cuta da kuma maganin cutar kansa. Wannan mahaɗin yana da yuwuwar amfani a cikin ilmin sunadarai na magani, musamman a matsayin maganin warkewa wanda ke nufin hada sinadarin nucleic acid da hanyoyin rayuwa a cikin kwayoyin halitta masu cutarwa. Halayensa na musamman na tsarin yana ba da damar yin mu'amala mai kyau da manufofin halittu da ke cikin metabolism na DNA da RNA.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose wani nau'in ribose ne da aka gyara ta hanyar sinadarai, wanda ke ɗauke da ƙungiyoyi uku na benzoyloxy da aka haɗa a matsayin 1, 3, da 5 na tsarin ribofuranose. Wannan gyare-gyaren yana ƙara narkewa da kwanciyar hankali, yana mai da shi mai amfani a cikin aikace-aikacen roba daban-daban a cikin sinadarai na halitta da biochemistry. A matsayin kariya daga ribose, yana aiki a matsayin matsakaici a cikin haɗa nucleosides da nucleotides, mahimman abubuwan RNA da DNA. Abubuwan da ke cikinsa na musamman suna sa 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose su zama masu mahimmanci ga masu bincike da ke neman haɓaka sabbin wakilai na magani da kayan aiki a cikin sunadarai na nucleotide.
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2′-O-methyluridine CAS:2140-76-3
2′-O-Methyluridine wani nau'in nucleoside ne da ke faruwa a zahiri wanda ƙungiyar methyl ke haɗe da zarrarin iskar oxygen na matsayin 2′ na sukarin ribose a cikin uridine. Wannan gyare-gyaren yana haɓaka kwanciyar hankali da aikin ƙwayoyin RNA, yana mai da shi muhimmin sashi a cikin hanyoyin halittu daban-daban. 2′-O-Methyluridine yana taka muhimmiyar rawa a cikin tsari da aikin ribonucleic acid (RNAs), gami da RNA na manzo (mRNA) da canja wurin RNA (tRNA). Kasancewarsa na iya yin tasiri ga kwanciyar hankalin RNA, ingancin fassara, da hulɗa da sunadarai da sauran ƙwayoyin nucleic acid, wanda hakan ya sanya shi muhimmin abu a cikin nazarin ilimin halittar kwayoyin halitta da aikace-aikacen magani.
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adenosine sodium 5′-monophosphate* daga yisti CAS:4578-31-8
Adenosine 5′-monophosphate sodium (AMP) wani nucleotide ne da aka samo daga adenosine wanda ke taka muhimmiyar rawa a cikin metabolism na ƙwayoyin halitta. AMP yana da mahimmanci ga hanyoyin halitta daban-daban, gami da canja wurin makamashi, canja wurin sigina, da kuma a matsayin abin da zai sa a haɗa ATP da sauran nucleotides. Ana iya samun nau'in gishirin sodium na AMP daga yisti, wanda ke da wadataccen nucleotides saboda hanyoyin metabolism masu aiki. Ana amfani da wannan mahaɗin a fannin biochemistry da pharmacology azaman reagent na biochemical, ƙari na abinci, da ƙarin abinci, saboda fa'idodin kiwon lafiya da aikace-aikacensa wajen haɓaka metabolism na makamashi.
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2′-Deoxycytidine CAS:951-77-9
2′-Deoxycytidine wani nucleoside ne da ya ƙunshi sukari na deoxyribose da cytosine, wanda aka bambanta shi da rashin rukunin hydroxyl a matsayin 2′ na ribose. Wannan gyare-gyaren ya sanya shi muhimmin sashi na DNA, inda yake haɗuwa da guanine yayin haɗin tushe. 2′-Deoxycytidine yana taka muhimmiyar rawa a cikin metabolism na ƙwayoyin halitta da haɗa DNA, yana aiki a matsayin tubalin gini don deoxycytidine triphosphate (dCTP), wanda yake da mahimmanci don kwafi da gyara DNA. Bugu da ƙari, wannan nucleoside yana da mahimman tasiri a cikin binciken ilmin halitta na kwayoyin halitta, maganin ciwon daji, da dabarun rigakafi, yana nuna mahimmancinsa a cikin bincike na asali da aikace-aikacen asibiti.
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2,2′-cyclouridine CAS:3736-77-4
2,2′-Cyclouridine wani nau'in uridine ne mai amfani da bicyclic nucleoside, wanda aka siffanta shi da samuwar wani tsari na musamman mai zagaye wanda ya ƙunshi matsayin 2′ da 2′ na ribose reshe. Wannan gyaran tsarin yana ba da halaye na sinadarai daban-daban waɗanda ke tasiri ga kwanciyar hankali da ayyukan halittu. 2,2′-Cyclouridine ya sami sha'awa a fannin ilmin sinadarai da ilmin sinadarai na magani saboda yuwuwar amfani da shi a matsayin maganin rigakafi da kuma binciken RNA. Ikonsa na daidaita hulɗar nucleic acid ya sa ya zama kayan aiki mai mahimmanci don nazarin alaƙar tsarin RNA da aikin aiki, wanda hakan zai iya haifar da ci gaba a dabarun magani da ke niyya ga kamuwa da cututtukan ƙwayoyin cuta da cututtukan kwayoyin halitta.
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2-Aminoadenosine CAS:2096-10-8
2-Aminoadenosine wani abu ne da ke faruwa a zahiri daga adenosine, wanda aka bambanta shi da kasancewar ƙungiyar amino a matsayi na 2 na sukarin ribose. Wannan gyare-gyaren yana canza halayensa da ayyukansa na biochemical sosai, yana mai da shi muhimmin kwayar halitta a cikin matakai daban-daban na ilimin halittar jiki. 2-Aminoadenosine yana da hannu a cikin siginar ƙwayoyin halitta, metabolism, da hanyoyin sarrafawa, gami da waɗanda ke da alaƙa da homeostasis na makamashi da kuma watsawar jijiyoyi. Amfanin maganin sa na warkewa ya shafi fannoni da yawa, gami da ilimin halittar jiki da zuciya, inda zai iya yin tasiri ga martanin ƙwayoyin halitta ga damuwa da rauni. Yayin da bincike ke ci gaba, 2-aminoadenosine yana da alƙawarin haɓaka sabbin mahadi masu aiki da magunguna masu warkewa.
