Candesartana Cilexetila CAS: 145040-37-5

Candesartan cilexetil wani ƙwararren mai ƙarfi ne, mai tsayi, da zaɓin angiotensin II nau'in mai karɓar mai karɓar AT1 antagonist, candesartan.Yana da sauri hydrolyzed zuwa candesartan a lokacin sha gastrointestinal fili.Bayan hydrolysis na candesartan cilexetil zuwa candesartan a lokacin sha na gastrointestinal fili, candesartan zažužžukan gasa tare da angiotensin II don dauri na angiotensin II receptor subtype 1 AT1 a cikin jijiyoyin bugun gini santsi tsoka, toshe angiotensin II-tsakanin vasoconstriction da haifar da vasodilatation.Bugu da ƙari, antagonism na AT1 a cikin glandon adrenal yana hana angiotensin II-stimulated aldosterone kira da ɓoye ta hanyar adrenal cortex;sodium da fitar ruwa suna karuwa, sannan kuma rage yawan ƙwayar plasma da hawan jini.