Tofacitinib CAS:477600-75-2 Mai Kaya na Masana'anta

Tofacitinib shine farkon ƙaramin ƙwayar kinase mai hana ƙwayoyin cuta da aka amince da shi don maganin RA. Tofacitinib wani mai hana ƙwayoyin cuta ne na nau'ikan Janus kinase guda huɗu (JAK): JAK1, JAK2, JAK3, da Tyk2. Tofacitinib yana aiki ta hanyar hana phosphorylation da kunna masu canza sigina da masu kunna kwafi (STATs), ta haka yana hana samar da masu shiga tsakani na kumburi a cikin kyallen haɗin gwiwa.

Yi oda ko Nemi Farashi

Cikakken Bayani game da Samfurin

Alamun Samfura

Aikace-aikace da Tasiri

Tofacitinib magani ne don maganin cututtukan rheumatoid arthritis (RA), psoriasis, cututtukan hanji mai kumburi, da sauran cututtukan garkuwar jiki, da kuma hana ƙin dashen gabobi. Yana hana enzyme Janus kinase 3 (JAK3), wanda ke nufin yana tsoma baki ga hanyar siginar JAK-STAT wadda ke watsa bayanai a wajen tantanin halitta zuwa cikin kwayar halitta, yana tasiri ga kwafi na DNA. Kwanan nan an nuna shi a cikin samfurin murine na amosanin gabbai, tofacitinib ya inganta cutar cikin sauri ta hanyar hana samar da masu shiga tsakani na kumburi da kuma danne kwayoyin halittar da suka dogara da STAT1 a cikin kyallen haɗin gwiwa. Wannan ingancin wannan samfurin cutar ya yi daidai da hana hanyoyin siginar JAK1 da 3, yana nuna cewa tofacitinib na iya yin amfani da fa'idar magani ta hanyoyin da ba wai kawai hana JAK3 ba.

Samfurin Samfuri

Shirya Samfurin:

Ƙarin Bayani:

Tsarin aiki	C16H20N6O
Gwaji	99%
Bayyanar	Foda mai launin fari
Lambar CAS	477600-75-2
shiryawa	25KG
Rayuwar shiryayye	Shekaru 2
Ajiya	A adana a wuri mai sanyi da bushewa
Takardar shaida	ISO.