Sabon binciken Vitamin K2 MK7

Bitamin K2 MK7 (Menaquinone-7) wani muhimmin sinadari ne na Bitamin K2 wanda ke aiki a jiki, wanda ke samun kulawa sosai saboda muhimmancinsa a fannin lafiyar zuciya da ƙashi. Ga cikakken bayani.

· Asalin Sinadarai: Vitamin K2 wani ɓangare ne na dangin menaquinone (MK), wanda ke da alaƙa da sarkar gefe na raka'o'in prenyl masu maimaitawa. MK7 musamman yana da raka'o'in isoprenoid guda 7 ("MK" yana nufin Menaquinone, "7" yana nufin tsawon sarkar).

· Tushen Halitta:

· Abincin da aka yi da fermented: Abincin da ya fi wadata a abinci shine natto (abincin gargajiya na Japan da aka yi da waken soya). Sauran abincin da aka yi da fermented kamar wasu cuku (misali, Gouda, Brie) da sauerkraut suna ɗauke da ƙananan adadin da ba su da bambanci.

· Tushen Dabbobi: Ana samunsa a cikin ƙananan adadin a cikin gwaiduwa, hanta, da nama mai kitse daga dabbobin da aka ciyar da ciyawa.

· Karin Abinci: Ana samunsa sosai a matsayin kari na abinci, wanda galibi ana samunsa ne daga fermentation na natto ko kuma an samar da shi ta hanyar roba. Sau da yawa ana haɗa shi da Vitamin D3 da calcium don tasirin haɗin gwiwa.

Wannan shine babban ra'ayin da ya bambanta Vitamin K2 (musamman MK7):

· Yana kunna Matrix Gla Protein (MGP): MGP wani abu ne mai ƙarfi da ke hana ƙwayoyin jini yin kauri. Yana ɗaurewa da ions na calcium a cikin bangon jijiyoyin jini kuma yana hana su shiga cikin kyallen jiki masu laushi (jijiyoyin jini, kodan). MK7 yana kunna MGP. Idan babu isasshen K2, MGP yana ci gaba da aiki, yana ƙara haɗarin tauri na jijiyoyin jini da cututtukan zuciya.

· Yana kunna Osteocalcin: Osteocalcin furotin ne da osteoblasts (ƙwayoyin gina ƙashi) ke samarwa. Aikinsa shine ɗaure sinadarin calcium da haɗa shi cikin matrix na ƙashi, yana ƙarfafa ƙashi. MK7 yana kunna osteocalcin.

· Ma'anar "Daraktan Calcium": Ka yi tunanin Vitamin D a matsayin "mai tsaron ƙofa" wanda ke tabbatar da isasshen sinadarin calcium yana shiga cikin jini daga hanji. Vitamin K2 (MK7) yana aiki a matsayin "darektan zirga-zirga" ko "mai kula da ababen hawa," yana tabbatar da cewa an saka sinadarin calcium a cikin ƙasusuwa (ta hanyar osteocalcin) kuma an hana shi shiga cikin jijiyoyin jini (ta hanyar MGP).

1. Lafiyar Zuciya da Jijiyoyin Jiki:

· Yana Rage Taurin Jijiyoyi da Calcification: Nazarin lura da kuma shiga tsakani da dama sun danganta yawan shan K2 (MK7) da raguwar haɗarin kamuwa da cututtukan zuciya, calcification na jijiyoyin jini, da kuma mace-mace. Nazarin ROTTERDAM wani shahararren bincike ne da ke nuna wannan fa'idar.

· Yana Inganta Juyawa: An nuna cewa ƙarin (misali, 180-360 µg/rana tsawon shekaru da yawa) yana inganta sassaucin jijiyoyin jini.

2. Lafiyar Kashi:

· Yana Rage Hadarin Karyewa: Musamman mata bayan daina al'ada. K2 yana aiki tare da Vitamin D da calcium don inganta yawan ma'adanai na ƙashi (BMD) da rage yawan karyewar ƙashi (ƙafafun baya da kugu).

· Yana Hana Kashi: Ta hanyar kunna osteocalcin gaba ɗaya, yana tallafawa tsarin sake fasalin ƙashi, yana fifita samuwar ƙashi fiye da resorption.

3. Sauran Amfani Masu Yiwuwa (Binciken da ke Tasowa):

· Jin Insulin da Ciwon Suga: Osteocalcin, idan K2 ya kunna shi, na iya taka rawa wajen inganta jin Insulin.

· Lafiyar Koda: Yana iya taimakawa wajen hana sinadarin calcium a cikin jijiyoyin jini ga marasa lafiya da ke fama da cutar koda ta yau da kullun (CKD), kodayake amfani da shi a cikin CKD yana buƙatar kulawar likita saboda yuwuwar rikitarwa.

· Lafiyar Hakora: Kamar ƙashi, yana iya taimakawa wajen haƙoran da aka haƙo ta hanyar osteocalcin.

· Lafiyar Fahimta: Wasu bincike na farko sun danganta lafiyar jijiyoyin jini (wanda K2 ke tallafawa) da raguwar haɗarin raguwar fahimi.

Siffar Vitamin K2 MK7 Vitamin K2 MK4

Asalinsa ya samo asali ne daga fermentation na ƙwayoyin cuta (natto). Ana samunsa a cikin kayayyakin dabbobi; yawancin kari an yi su ne da roba.

Rabin Rai (~ awanni 72). Yana ba da daidaiton matakan jini mai ɗorewa daga allura ɗaya. Gajere (~ awanni 1-2). Yana buƙatar yawan shan magani (sau da yawa a rana).

Samuwar halitta Mai kyau kwarai da gaske; tsawon rabin rayuwarsa yana haifar da ƙarin matakan jini. Kyakkyawan amma saurin sharewa yana iyakance tarin nama.

Yawanci ana amfani da shi wajen ƙara yawan shan magani (90-360 µg/rana). Sau da yawa ana amfani da shi a cikin allurai na magani (1.5-45 mg/rana) a cikin nazarin asibiti.

Amfani na Farko Lafiyar rigakafi na dogon lokaci ga ƙashi da jijiyoyin jini (karin abinci). Maganin da likita ya rubuta (a Japan) don osteoporosis da asarar ƙashi da steroid ke haifarwa.

Shaida Mai ƙarfi bayanai game da cututtuka da kuma ƙaruwar gwaje-gwajen asibiti don fa'idodin zuciya da jijiyoyin jini. Bayanan gwaji na asibiti masu ƙarfi don fa'idodin ƙashi a allurai masu yawa, na magunguna.

Kammalawa: Ana fifita MK7 don ƙarin abinci na yau da kullun saboda ingantaccen maganin pharmacokinetics (tsawon rabin rai), yana ba da damar yin allura sau ɗaya a rana da kuma kunna sunadaran da ke dogara da K akai-akai.

· Karin Maganin da Aka Saba Amfani da Shi: Yana farawa daga microgram 90 (µg) zuwa 360 µg a kowace rana. Yawancin bincike kan fa'idodin zuciya da jijiyoyin jini suna amfani da kusan 180-200 µg/rana.

· Tsaro: Babu wani abu da aka sani game da guba a cikin allurai da aka ba da shawarar ga jama'a. Ba a san ko akwai wani nau'in guba da aka sani ba.

· Muhimmin Hulɗa - Magungunan Hana Coagulants (Warfarin/Coumadin):

· Bitamin K yana hana tasirin Warfarin. Marasa lafiya da ke shan Warfarin dole ne su ci gaba da shan Vitamin K akai-akai (daga abinci da kari) don kiyaye yawan maganin da suke sha ya daidaita.

· Bai kamata su fara ko dakatar da ƙarin K2 ba tare da kulawar likita da kuma yawan sa ido kan INR ba. Sabbin magungunan hana ɗaukar ciki (DOACs kamar apixaban, rivaroxaban) ba sa hulɗa da Vitamin K.

· Haɗin gwiwa: Kullum a sha tare da Vitamin D3. Suna da ƙarfi wajen haɗa sinadarai. Calcium da magnesium suma suna da mahimmanci wajen haɗa sinadarai.

· Siffa: Man shafawa masu laushi ko kuma capsules masu ɗauke da mai (misali, man zaitun, man MCT) sun dace, domin Vitamin K2 yana narkewa da mai.

· Tsarin Haɗaka: Nemi samfuran da suka haɗa da K2 (MK7) + D3. Ƙara ƙaramin adadin Vitamin K1 kuma yana iya zama da amfani ga cikakken matsayin K.

· Inganci: Zaɓi samfuran da ke amfani da all-trans MK7 (nau'in bioactive; wasu samfuran roba na iya ƙunsar isomer cis mai ƙarancin aiki).

· Ajiya: A ajiye a wuri mai sanyi da duhu. A ajiye a cikin kari idan an kare shi daga haske da zafi.

A taƙaice, Vitamin K2 MK7 muhimmin sinadari ne wanda ke tura sinadarin calcium zuwa kwarangwal yayin da yake kare jijiyoyin jini da kyallen jiki masu laushi daga ƙashi. Tsawon rabin rayuwarsa da kuma ƙarfin shaidar da ke tabbatar da hakan ya sanya shi muhimmin sashi na tsarin kiwon lafiya na rigakafi, musamman ga lafiyar zuciya da ƙashi, idan aka yi amfani da shi tare da Vitamin D3.