L-Lactate dehydrogenase CAS:9001-60-9

Tasirin L-Lactate dehydrogenase (LDH) ya haɗa da rawar da yake takawa a cikin metabolism na makamashin tantanin halitta da kuma rawar da yake takawa wajen canza pyruvate zuwa lactate. LDH yana taimakawa wajen kula da daidaiton makamashi a cikin tantanin halitta ta hanyar sauƙaƙe canza pyruvate, wani abu da ya samo asali daga metabolism na glucose, zuwa lactate. Wannan tsari, wanda aka sani da anaerobic glycolysis, yana faruwa ne lokacin da wadatar iskar oxygen ta yi ƙasa.

LDH kuma yana taka muhimmiyar rawa wajen sake amfani da lactate. A lokacin motsa jiki mai tsanani ko kuma lokacin da iskar oxygen ta yi ƙasa, lactate na iya taruwa a cikin kyallen takarda. LDH yana taimakawa wajen sake amfani da lactate ta hanyar mayar da shi pyruvate, wanda za'a iya amfani da shi azaman substrate don samar da makamashi ko kuma a canza shi zuwa glucose ta hanyar gluconeogenesis. Wannan tsarin sake amfani da lactate yana bawa ƙwayoyin halitta damar amfani da lactate yadda ya kamata a matsayin tushen makamashi kuma yana taimakawa wajen hana tarin lactate, wanda zai iya zama illa ga aikin ƙwayoyin halitta.

LDH yana da aikace-aikace da dama a fannin likitanci. Ɗaya daga cikin manyan aikace-aikacensa shine a matsayin alamar gano wasu cututtuka. Matakan LDH masu yawa a cikin jini na iya nuna lalacewar nama ko kasancewar cututtuka kamar lalacewar hanta, bugun zuciya, da wasu nau'ikan ciwon daji. Ana yawan sa ido kan matakan LDH a wuraren asibiti don tantance ci gaban cutar da kuma martanin da ake bayarwa ga magani.