Tofacitinib CAS: 477600-75-2 Mai Bayar da Manufacturer

Tofacitinib magani ne don maganin rheumatoid amosanin gabbai (RA), psoriasis, cututtukan hanji mai kumburi, da sauran cututtuka na rigakafi, da kuma rigakafin ƙin yarda da dashen gabobin.Yana da mai hana enzyme Janus kinase 3 (JAK3), wanda ke nufin cewa yana tsoma baki tare da hanyar siginar JAK-STAT wanda ke watsa bayanai a waje da tantanin halitta a cikin kwayar halitta, yana rinjayar rubutun DNA.Kwanan nan an nuna shi a cikin samfurin murine na kafaffen arthritis, tofacitinib ya inganta cutar da sauri ta hanyar hana samar da masu shiga tsakani da kuma hana STAT1 masu dogara ga kwayoyin halitta a cikin haɗin gwiwa. Hanyoyi, suna ba da shawarar cewa tofacitinib na iya yin amfani da fa'idodin warkewa ta hanyoyin da ba su keɓance ga hana JAK3 ba.