4-Nitrophenyl Beta-D-glucuronide CAS: 10344-94-2

4-Nitrophenyl Beta-D-glucuronide wani sinadari ne da aka kafa ta hanyar haɗa kwayar glucose zuwa ƙungiyar 4-nitrophenyl ta hanyar haɗin gwiwar glycosidic.Ana amfani da shi a matsayin mai mahimmanci a cikin ƙididdigar enzymatic don gano kasancewar da aiki na β-glucuronidase, wani enzyme da ke cikin metabolism na kwayoyi daban-daban da xenobiotics a cikin dabbobi masu shayarwa.Lokacin da β-glucuronidase ya kasance, yana raba haɗin glycosidic tsakanin glucose. da ƙungiyar 4-nitrophenyl, wanda ya haifar da sakin 4-nitrophenol, wanda za'a iya gano shi ta hanyar spectrophotometric a 400-420 nm.Wannan halayen enzymatic yana ba da ma'aunin ƙididdigewa na ayyukan β-glucuronidase kuma galibi ana amfani da shi azaman kayan aiki don gano magunguna, nazarin toxicology, da bincike na asibiti.

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Gano aikin β-glucuronidase: 4-NPBG ana amfani da shi azaman madaidaicin chromogenic don tantance kasancewar da ayyukan β-glucuronidase a cikin samfuran halitta daban-daban.Enzyme yana raba haɗin glycosidic na 4-NPBG, yana samar da 4-nitrophenol, wanda za'a iya auna ta amfani da spectrophotometry.

Nazarin metabolism na ƙwayoyi: Tun da β-glucuronidase yana taka muhimmiyar rawa a cikin metabolism na kwayoyi da xenobiotics, ana iya amfani da 4-NPBG don tantance ayyukan wannan enzyme a cikin nazarin metabolism na miyagun ƙwayoyi.Yana taimakawa wajen fahimtar girman da motsin halayen halayen glucuronidation, waɗanda ke da mahimmanci don kawar da ƙwayoyi da bioavailability.

Nazarin Toxicology: Wasu mahadi masu guba za a iya daidaita su kuma a fitar dasu a cikin nau'in glucuronide conjugates.Ta amfani da 4-NPBG a matsayin ma'auni, masu bincike zasu iya bincika ayyukan β-glucuronidase a cikin kyallen takarda ko layin salula don kimanta yiwuwar guba ko mummunan tasirin mahadi.

Binciken asibiti: Ma'aunin aikin β-glucuronidase ta amfani da 4-NPBG ana iya amfani dashi a cikin saitunan asibiti don tantance wasu cututtuka ko yanayi.Matakan da ba na al'ada ko aiki na β-glucuronidase na iya nuna wasu cututtukan ƙwayoyin cuta, rashin aikin hanta, ko ciwon daji.

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Abun ciki	Saukewa: C12H13NO9
Assay	99%
Bayyanar	Farin foda
CAS No.	10344-94-2
Shiryawa	Karami da girma
Rayuwar Rayuwa	shekaru 2
Adana	Ajiye a wuri mai sanyi da bushewa
Takaddun shaida	ISO.